Prolactin receptor
Milk yield
Coding,
SNP
Bos taurus
cattle - (species)
Domesticated
Candidate Gene
Viitala S; Szyda J; Blott S ; et al. (2006)
The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein[...]
GP00000927
PRLR
P16471
Physiology
Ser18Asn
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
Prolactin receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
Prolactin receptor
Feather (slow-feathering ; delay)
Other,
Insertion
Gallus gallus
chicken - (species) D
Domesticated
Linkage Mapping
Elferink MG; Vallée AA; Jungerius AP ; et al. (2008)
Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken.
1 Additional References
GP00002280
PRLR
P16471
Morphology
tandem duplication of 176324 basepairs resulting in a partially duplicated PRLR (dPRLR) gene nearly identical to the original PRLR ; except for its lack of a 149-amino acid C-terminal tail - which may titrate PRL ligands and act as a dominant-negative receptor
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Prolactin receptor
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Prolactin receptor
Feather (slow-feathering ; delay)
Coding,
Deletion
Meleagris gallopavo mexicana
(subspecies) D
Domesticated
Association Mapping
Derks MFL; Herrero-Medrano JM; Crooijmans RPMA ; et al. (2018)
Early and late feathering in turkey and chicken: same gene but different mutations.
GP00002281
PRLR
P16471
Morphology
g.9426018_9426022delTTGGT p.Glu726Aspfs*7 truncated PRLR protein that lacks 98 C-terminal AA ; this truncated PRLR protein is strikingly similar to the protein encoded by the slow feathering K allele in chicken
Meleagris gallopavo mexicana
(subspecies)
Meleagris gallopavo mexicana
(subspecies) D
Prolactin receptor
Meleagris gallopavo mexicana
(subspecies)
Published - Accepted by Curator
Prolactin receptor
Hair (slick ; short ; thermotolerance)
Thermoregulation (tolerance to warm climate)
Coding,
Deletion
N
Bos taurus
cattle - (species) D
Domesticated
Littlejohn MD; Henty KM; Tiplady K ; et al. (2014)
Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.
GP00002282
PRLR
P16471
Morphology
Physiology
g.39136559delC p.Leu462* N
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
Prolactin receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
Prolactin receptor
Hair (slick ; short)
Thermoregulation (tolerance to warm climate)
Coding,
SNP
N
Bos taurus
cattle - (species) D
Domesticated
Porto-Neto LR; Bickhart DM; Landaeta-Hernandez AJ ; et al. (2018)
Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor.
GP00002283
PRLR
P16471
Morphology
Physiology
g.39136571C>A p.Ser465* N
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
Prolactin receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
Prolactin receptor
Hair (slick ; short)
Thermoregulation (tolerance to warm climate)
Coding,
SNP
N
Bos taurus
cattle - (species) D
Domesticated
Porto-Neto LR; Bickhart DM; Landaeta-Hernandez AJ ; et al. (2018)
Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor.
GP00002284
PRLR
P16471
Morphology
Physiology
g.39136666C>T p.Arg497* N
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
Prolactin receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
Prolactin receptor
Fertility
Cis-regulatory,
Insertion
Sus scrofa domesticus
domestic pig - (subspecies) D
Domesticated
Linkage Mapping
Sironen A; Fischer D; Laiho A ; et al. (2014)
A recent L1 insertion within SPEF2 gene is associated with changes in PRLR expression in sow reprodu[...]
1 Additional References
GP00002339
PRLR
P16471
Physiology
L1 insertion in sperm-factor SPEF2 gene causes sperm defect but also downregulation of PRLR
Sus scrofa domesticus
domestic pig - (subspecies)
Sus scrofa domesticus
domestic pig - (subspecies) D
Prolactin receptor
Sus scrofa domesticus
domestic pig - (subspecies)
Published - Accepted by Curator